Cellulose based nanofiber-assisted stabilization of cationic ethosomes for skin penetration of bleomycin sulphate in the treatment of skin cancer
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View abstract on PubMed
Summary
This summary is machine-generated.This study enhances cationic ethosomes for skin cancer treatment by embedding them in nanofibers. This improves stability and skin retention, potentially increasing therapeutic efficacy.
Area Of Science
- Nanomedicine
- Materials Science
- Dermatology
Background
- Skin cancer is a growing global health concern.
- Nano-vesicular drug delivery systems show promise but face stability and skin retention challenges.
- Cationic ethosomes loaded with bleomycin sulphate (BLM) were previously developed for skin cancer treatment.
Purpose Of The Study
- To enhance the stability and skin retention of bleomycin sulphate-loaded cationic ethosomes.
- To improve the storage conditions and achieve sustained release of the drug.
- To potentially increase the efficacy of skin cancer therapy.
Main Methods
- Preparation of BLM-loaded cationic ethosomes using thin film hydration.
- Incorporation of ethosomes into nanofibers via electrospinning.
- Characterization of morphology, drug release kinetics, ex-vivo skin permeation, in-vitro cytotoxicity, and in-vivo anticancer activity.
Main Results
- The nanofiber formulation exhibited smooth surface morphology and enhanced stability.
- Favorable skin retention was observed in ex-vivo assessments.
- In-vitro studies showed improved cytotoxic effects, and in-vivo studies indicated suitability for topical use.
Conclusions
- Embedding cationic ethosomes in nanofibers stabilizes the formulation.
- This approach provides good retention time for the drug delivery system in skin cancer therapy.
- The developed nanofiber formulation shows potential for improved topical treatment of skin cancer.
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