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RNF186 gene variant and zonulin levels in inflammatory bowel disease: A pilot study
Elif Özdemir Güneri1, Resul Kahraman2, Merve Nur Ataş1
1Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye; Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkiye.
Background And Study Aim:
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by inflammation and ulceration of the intestinal mucosa, represented by Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study is to investigate the relationship between the Ring Finger Protein 186 (RNF186) rs3806308 variant and IBD, as well as to determine whether zonulin levels are associated with IBD.
Patients And Methods:
Ninety-nine patients with inflammatory bowel disease were included in the study. The real-time PCR method was used to detect RNF186 gene polymorphism. Also serum zonulin levels were determined by using Enzyme Linked Immunosorbent Assay (ELISA) technique.
Results:
No difference was found between the groups in terms of RNF186 genotype and allele distributions (p > 0.05). CC genotype was associated with high levels of C-reactive protein (CRP) in total patients and CD compared to CT (p < 0.05).
Conclusion:
The present study is the first study conducted in our country in terms of examining RNF 186 gene polymorphism and serum zonulin levels.
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