Search

Search

Home
...
Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Artificial intelligence and colorectal neoplasia detection performances in patients with positive fecal immunochemical test: Meta-analysis and systematic review

Artificial intelligence and colorectal neoplasia detection performances in patients with positive fecal immunochemical test: Meta-analysis and systematic review

Marco Spadaccini ^1,2, Cesare Hassan ^1,2, Yuichi Mori ^3,4, Natalie Halvorsen ³, Antonio Z Gimeno-García ^5,6, Hirotaka Nakashima ⁷, Antonio Facciorusso ⁸, Harsh K Patel ⁹, Giulio Antonelli ^10,11, Kareem Khalaf ¹², Tommy Rizkala ², Daryl Ramai ¹³, Emanuele Rondonotti ¹⁴, Shunsuke Kamba ¹⁵, Roberta Maselli ^1,2, Loredana Correale ², Michael Bretthauer ³, Pradeep Bhandari ¹⁶, Prateek Sharma ⁹, Douglas K Rex ¹⁷, Alessandro Repici ^1,2,

Marco Spadaccini ^1,2, Cesare Hassan ^1,2, Yuichi Mori ^3,4

¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
²Endoscopy Unit, Humanitas Clinical Center - IRCCS, Rozzano, Italy.
³Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway.
⁴Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
⁵Servicio de Gastroenterología, Hospital Universitario de Canarias, Instituto Universitario de Tecnologías Biomédicas (ITB), Tenerife, Spain.
⁶Departamento de Medicina Interna, Centro de Investigación Biomédica de Canarias (CIBICAN), Universidad de La Laguna, Tenerife, Spain.
⁷Department of Gastroenterology, Foundation for Detection of Early Gastric Carcinoma, Tokyo, Japan.
⁸Department of Medical Sciences, Section of Gastroenterology, University of Foggia, Foggia, Italy.
⁹Department of Gastroenterology and Hepatology, Kansas City VA Medical Center, Kansas City, Kansas, USA.
¹⁰Gastroenterology and Digestive Endoscopy Unit, Ospedale dei Castelli, Rome, Italy.
¹¹Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, "Sapienza" University of Rome, Rome, Italy.
¹²The Center for Therapeutic Endoscopy and Endoscopic Oncology, St. Michael's Hospital, University of Toronto, Toronto, Canada.
¹³Department of Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, Utah, USA.
¹⁴Gastroenterology Unit, Valduce Hospital, Como, Italy.
¹⁵Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.
¹⁶Department of Gastroenterology, Queen Alexandra Hospital, Portsmouth, UK.
¹⁷Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

⁰Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society +

|

May 6, 2025

|

May 6, 2025

Related Experiment Videos

Contact us if these videos are not relevant.

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples

Published on: April 25, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

See all related videos

View abstract on PubMed

Summary

This summary is machine-generated.

Computer-aided detection (CADe) systems improve adenoma and serrated lesion detection during colonoscopy in fecal immunochemical test-positive populations. However, CADe did not significantly impact advanced adenoma detection and increased nonneoplastic polyp removal.

Area Of Science

Gastroenterology
Endoscopy
Cancer Screening

Background

Fecal immunochemical testing (FIT) followed by colonoscopy is a preferred colorectal cancer screening strategy.
The impact of advanced technologies on adenoma detection rates in FIT-positive populations remains inconsistent.

Purpose Of The Study

To evaluate the effectiveness of computer-aided detection (CADe) systems in randomized trials for colorectal neoplasia detection.
To assess CADe's impact on adenoma detection rates within the FIT-positive population.

Main Methods

Systematic search of MEDLINE, EMBASE, and Scopus databases up to September 2023.
Inclusion of randomized controlled trials assessing CADe system diagnostic accuracy for colorectal neoplasia.
Primary outcome: pooled adenoma detection rate; secondary outcomes: adenoma, advanced adenoma, serrated lesions, and nonneoplastic polyp detection rates.

Main Results

Ten trials involving 5421 patients were analyzed.
CADe significantly increased adenoma detection rate (0.62 vs. 0.52; RR 1.19) and serrated lesion detection.
No significant difference in advanced adenoma detection; however, nonneoplastic polyp removal increased (0.45 vs. 0.34).

Conclusions

CADe enhances adenoma and serrated lesion detection in FIT-positive individuals undergoing colonoscopy.
The benefit of CADe for advanced adenoma detection was not statistically significant.
Increased detection and removal of nonneoplastic polyps were observed with CADe use.

Keywords:

CRC screening artificial intelligence colorectal cancer polyp/adenoma

Related Experiment Videos

Contact us if these videos are not relevant.

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples

Published on: April 25, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

See all related videos

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies