Related Experiment Video
Updated: May 12, 2025

10:01
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Published on: August 2, 2022
6.2K
Immunotherapy in lung cancer brain metastases
Eunice Paisana1, Rita Cascão1, Magda Alvoeiro2
1GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal.
NPJ Precision Oncology
|May 6, 2025
Abstract:
Brain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunotherapeutic strategies, and promising biomarkers in NSCLC patients.

