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SARS-CoV-2 spike protein: structure, viral entry and variants.

Bing Chen1, Michael Farzan2,3, Hyeryun Choe4

  • 1Division of Molecular Medicine, Boston Children's Hospital, and Department of Paediatrics, Harvard Medical School, Boston, MA, USA. bchen@crystal.harvard.edu.

Nature Reviews. Microbiology
|May 6, 2025
PubMed
Summary

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is key to viral entry and immune response. Understanding its structure and function aids in developing new vaccines and therapeutics against COVID-19 variants.

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