Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Programmatic encapsulation of hydrazine within polynitro frameworks for superior self-redox systems.

Science advances·2026
Same author

Root Canal Location Accuracy: Dynamic Navigation Verses Freehand in Extracted Human Molars - A Randomized In Vitro Study.

International dental journal·2026
Same author

Spatial distribution of per- and polyfluoroalkyl substances in the Yellow River basin: Role of suspended sediment on the PFAS partition and accumulation.

Journal of hazardous materials·2026
Same author

Machine learning-fugacity framework reveals the fate and environmental drivers of per- and polyfluoroalkyl substances in a mountainous river.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Recent advances and future prospects in energetic binary C-N anions.

Chemical communications (Cambridge, England)·2026
Same author

Mechanistic shift of bioaccumulation from exposure-controlled to trophic-driven for per- and polyfluoroalkyl substances along estuary-open sea gradient.

Environment international·2026

Related Experiment Video

Updated: May 12, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.8K

Long non-coding RNA in IgA nephropathy: a comprehensive review.

Xiaoxuan Huang1, Lan Chen1, Jinxuan He1

  • 1Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Renal Failure
|May 7, 2025
PubMed
Summary

Long non-coding RNAs (lncRNAs) are increasingly implicated in Immunoglobulin A nephropathy (IgAN) pathogenesis. This review consolidates lncRNA research in IgAN, highlighting their roles and potential as biomarkers for this common kidney disease.

Keywords:
IgA nephropathybiomarkerslncRNAtherapeutic targets

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.6K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

14.9K

Related Experiment Videos

Last Updated: May 12, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.8K
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.6K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

14.9K

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, often leading to end-stage kidney disease (ESKD).
  • The exact mechanisms driving IgAN progression are not fully understood.
  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression with altered patterns observed in various diseases, including IgAN.

Purpose of the Study:

  • To review current literature on the role of lncRNAs in the pathogenesis of IgAN.
  • To consolidate findings on specific lncRNAs implicated in IgAN.
  • To identify potential future research directions and therapeutic targets related to lncRNAs in IgAN.

Main Methods:

  • Bioinformatic analyses of IgAN patient data.
  • Identification of differentially expressed lncRNAs.
  • Correlation studies linking lncRNA expression to clinical markers and disease severity.
  • Experimental validation of lncRNA involvement in IgAN pathogenesis.

Main Results:

  • Several lncRNAs (e.g., HOTAIR, H19, MALAT1, MIR31HG, Lnc-TSI, lnc-CHAF1B-3, ICR, PTTG3P, CRNDE) show differential expression or genetic links to IgAN.
  • Specific lncRNAs are associated with IgAN susceptibility, clinical features, renal fibrosis, and disease progression.
  • Serum H19 may act as a protective factor, while others like ICR correlate with IgAN severity.

Conclusions:

  • lncRNAs play significant roles in IgAN pathogenesis and progression.
  • Certain lncRNAs show potential as biomarkers for IgAN diagnosis, prognosis, and therapeutic targets.
  • Further research is crucial to elucidate lncRNA functions and develop effective lncRNA-based therapies for IgAN.