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Relationship between autoimmunity and COPD: an investigation based on proteomic profiling and antinuclear antibody screening

  • 0Biochemistry and Phytochemistry Research Division, Jubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala.
Journal of Immunoassay & Immunochemistry +

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May 7, 2025

|

May 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Autoimmunity may play a role in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis. This study found specific proteins and anti-nuclear antibodies (ANA) in COPD patients, suggesting immune dysregulation and potential new biomarkers.

Area Of Science

  • Immunology
  • Proteomics
  • Pulmonology

Background

  • Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with significant global health impact.
  • Inflammation, oxidative stress, and autoimmunity are key factors influencing COPD phenotypes.

Purpose Of The Study

  • To investigate the role of autoimmunity in stable and exacerbated COPD.
  • To identify molecular mechanisms and potential biomarkers associated with autoimmunity in COPD.

Main Methods

  • Label-free mass spectrometry was used to analyze plasma proteins from COPD patients and controls.
  • Functional annotation and pathway enrichment analysis identified proteins linked to autoimmune pathways.
  • Immunological assays (ANA ELISA, indirect immunofluorescence) assessed anti-nuclear antibody prevalence.

Main Results

  • Proteins such as XRCC2, phospholipase D, SHPRH, and Protocadherin-β were differentially expressed and linked to autoimmune pathways.
  • Enriched pathways included uPAR-mediated signaling, mTOR, PI3K/Akt, ARF6, and S1P signaling.
  • Anti-nuclear antibody (ANA) positivity was observed in 47% of stable and 36% of exacerbated COPD patients, with a speckled pattern common.

Conclusions

  • Autoimmunity is potentially implicated in the pathogenesis of COPD.
  • Findings suggest phenotype-specific immune dysregulation in COPD.
  • Identified proteins and antibodies may serve as future biomarkers for COPD and targets for therapy.

Keywords:

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