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Related Concept Videos

Dialysis01:27

Dialysis

226
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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A Mixed Methods Study of Risk Factors for Frailty in Peritoneal Dialysis Patients.

Wei Cao1, Mingyu Cai2, Yuanchun Xu1

  • 1Department of Nursing, Amy Medical Center of PLA (Daping Hospital), Chongqing, China.

Journal of Clinical Nursing
|May 7, 2025
PubMed
Summary

This study identified key risk factors for frailty in peritoneal dialysis (PD) patients, including fatigue and low muscle strength. Understanding these factors is crucial for developing targeted interventions to improve patient care.

Keywords:
frailtymixed methodsperitoneal dialysisrisk factors

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Area of Science:

  • Nephrology
  • Gerontology
  • Public Health

Background:

  • Frailty is a significant concern in patients undergoing peritoneal dialysis (PD).
  • Identifying frailty phenotypes and associated risk factors is essential for effective patient management.
  • A comprehensive understanding requires integrating quantitative and qualitative patient data.

Purpose of the Study:

  • To investigate frailty phenotypes in PD patients using a convergent mixed methods approach.
  • To identify and analyze risk factors contributing to frailty in this population.
  • To provide a foundation for developing targeted interventions for PD patients.

Main Methods:

  • A cross-sectional mixed methods study was conducted with 213 PD patients.
  • Quantitative data collected via questionnaires and standardized scales (FFP, CCI, MNA-SF, MoCA, HADS).
  • Qualitative data gathered through semi-structured interviews with 19 pre-frail or frail PD patients.

Main Results:

  • 46.5% non-frail, 41.3% pre-frail, 12.2% frail PD patients identified.
  • Primary frailty phenotypes: fatigue and low muscle strength.
  • Key risk factors include age, sedentary behavior, comorbidities, nutritional status, cognitive function, polypharmacy, psychological state, and social connections.

Conclusions:

  • Frailty in PD patients is multifactorial, influenced by a range of physiological, psychological, and social elements.
  • Healthcare professionals can use identified risk factors to design targeted interventions.
  • Multidisciplinary collaboration is vital for comprehensive frailty management in PD patients.