Recent Developments in Deep Eutectic Solvents Applications in Liquid Chromatography: 2019-2025

Area of Science:

• Analytical Chemistry
• Green Chemistry

Background:

• Deep eutectic solvents (DES) are increasingly explored as alternatives to traditional chromatographic phases.
• Their unique physicochemical properties offer advantages in separation science.
• Recent advancements focus on their application in liquid and supercritical fluid chromatography.

Purpose of the Study:

• To review recent (post-2019) applications of DES in chromatography.
• To evaluate DES as greener alternatives for mobile and stationary phases.
• To discuss parameters influencing DES selection and their limitations in modern separations.

Main Methods:

• Literature review of publications since 2019.
• Analysis of DES properties relevant to chromatography (selectivity, peak shape, separation time).
• Assessment of environmental impact and practical limitations of DES.

Main Results:

• DES can improve separation selectivity, reduce peak tailing, and shorten analysis times.
• Key advantages include biodegradability, recyclability, and stability.
• Disadvantages include higher viscosity and potential degradation in aqueous solutions.

Conclusions:

• DES present a promising avenue for green chemistry in chromatography.
• Careful consideration of DES properties and limitations is crucial for successful implementation.
• Further research is needed to overcome current challenges in DES-based chromatographic separations.