Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Enzymes

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Charge localization, rectification, and transport in electrolyte patchy nanochannels.

Faraday discussions·2026

Same author

Plug flow down to the nanoscale can induce partial solidification of confined fluids.

Soft matter·2026

Same author

From mesoscopic to macroscopic models of reactive Brownian nanoparticles.

The Journal of chemical physics·2026

Same author

Chemically active droplets in crowded environments.

Physical review. E·2026

Same author

Unravel the rotational and translational behavior of a single squirmer in flexible polymer solutions at different Reynolds numbers.

Communications physics·2025

Same author

Control of encounter kinetics by chemically active droplets.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same journal

RNA-ligand complexes and the attenuation of neutral confinement in the evolution of RNA secondary structures.

Journal of the Royal Society, Interface·2026

Same journal

Individual detachment-reintegration events in homing pigeon flocks and the dominance of directional adjustment in their kinematic features.

Journal of the Royal Society, Interface·2026

Same journal

Thermal stress disrupts symbiotic fluid dynamics in bobtail squid.

Journal of the Royal Society, Interface·2026

Same journal

Distinct geometrical landscapes distinguish between modes of tristability in gene regulatory networks.

Journal of the Royal Society, Interface·2026

Same journal

Slow modulation of the contraction patterns in Physarum polycephalum.

Journal of the Royal Society, Interface·2026

Same journal

Moo-ving mountains: grazing agents drive terracette formation on steep hillslopes.

Journal of the Royal Society, Interface·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2025

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Published on: August 28, 2017

Active droplets controlled by enzymatic reactions.

Jacques Fries¹, Javier Diaz^2,3, Marie Jardat¹

¹Sorbonne Université, CNRS, Physico-Chimie des Electrolytes et Nanosystèmes Interfaciaux(PHENIX), 4 Place Jussieu, Paris 75005, France.

Journal of the Royal Society, Interface

|May 7, 2025

Summary

This summary is machine-generated.

Enzymes influence the formation and size of cellular condensates. Their concentration and movement dynamics are key factors in controlling biocondensate size and evolution, impacting cellular organization.

Keywords:

Brownian dynamics active droplets biocondensates reaction-diffusion systems

More Related Videos

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Related Experiment Videos

Last Updated: May 12, 2025

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Published on: August 28, 2017

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Area of Science:

Cell Biology
Biophysics
Biochemistry

Background:

Cellular condensates are crucial for eukaryotic cell organization.
Enzymatic reactions significantly impact condensate properties.
Understanding enzyme-protein interactions is key to cellular regulation.

Purpose of the Study:

To model the interplay between enzyme populations and a two-state protein.
To investigate how enzyme dynamics affect condensate formation and size.
To explore the role of enzyme concentration and movement in biocondensate evolution.

Main Methods:

Developed a generic model with explicit enzyme trajectories.
Employed Brownian dynamics simulations.
Utilized a hybrid Cahn-Hilliard-Cook and Brownian dynamics approach.

Main Results:

Enzyme concentration and diffusion govern condensate formation.
Enzyme dynamics influence droplet size selection.
Spatially dependent droplet growth arises from enzyme motion.

Conclusions:

Enzyme concentration and diffusion are critical for biocondensate formation and size control.
Explicitly modeling enzyme trajectories reveals mechanisms of condensate regulation.
This model provides insights into the dynamic control of cellular organization.