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CircAkap7: A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity

Jiaqin Liu1,2,3, Sa Liu1,2, Xiangyun Li1,2

  • 1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Genes & Diseases
|May 7, 2025
PubMed
Abstract

No abstract available in PubMed .

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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