Related Experiment Video
Updated: May 12, 2025
09:40
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
2.5K
Long noncoding RNA TUG1 promotes chondrosarcoma progression and M2 polarization
Chao Li1, Wei Wang1, Binlong Zhong1
1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Genes & Diseases
|May 7, 2025
Summary
The long non-coding RNA taurine up-regulated gene 1 (TUG1) promotes chondrosarcoma (CHS) progression by stabilizing EZH2 and repressing tumor suppressors. Exosomal TUG1 also fuels CHS growth by promoting M2 macrophage polarization.
Area of Science:
- Molecular Biology
- Oncology
- RNA Biology
Background:
- The role of long non-coding RNA taurine up-regulated gene 1 (TUG1) in cancer is increasingly recognized.
- Its specific involvement in chondrosarcoma (CHS) pathogenesis is largely unexplored.
Purpose of the Study:
- To investigate the function and mechanism of TUG1 in chondrosarcoma.
- To elucidate the regulatory pathways influenced by TUG1 in CHS development.
Main Methods:
- Analysis of TUG1 expression levels in CHS tissues.
- In vitro functional assays to assess TUG1's impact on CHS cell progression.
- Mechanistic studies involving ALYREF, EZH2, H3K27me3, and CPEB1.
- Investigation of exosomal TUG1 effects on M2 macrophage polarization.
Main Results:
- TUG1 expression is significantly elevated in chondrosarcoma.
- TUG1 promotes CHS cell proliferation and metastasis.
- TUG1 stabilizes EZH2 mRNA via ALYREF, leading to H3K27me3 enrichment and repression of the tumor suppressor CPEB1.
- Exosomal TUG1 promotes M2 macrophage polarization, further enhancing CHS progression.
Conclusions:
- TUG1 acts as an oncogene in chondrosarcoma.
- TUG1 regulates CHS progression through the EZH2/H3K27me3/CPEB1 axis and M2 macrophage polarization.
- TUG1 represents a potential therapeutic target for chondrosarcoma.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.6K
02:39lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
02:23Abnormal Proliferation
4.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
01:16TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
02:17The Tumor Microenvironment
6.4K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.4K