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Predisposing Factors for Idiopathic Granulomatous Mastitis: A Large Prospective Multicentric Study
Sadaf Alipour1,2, Maryam Tabatabaeian3, Parisa Aziminezhadan4
1Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Iranian Journal of Public Health
|May 7, 2025
Summary
Previous breastfeeding history significantly increases Idiopathic Granulomatous Mastitis (IGM) risk. Diabetes history is a risk factor, while oral contraceptive pill (OCP) use is protective against IGM.
Area of Science:
- Obstetrics and Gynecology
- Dermatology
- Endocrinology
Background:
- Idiopathic Granulomatous Mastitis (IGM) is a chronic inflammatory breast condition with unclear causes.
- Understanding IGM risk factors is crucial for diagnosis and management.
Purpose of the Study:
- To investigate potential risk factors associated with Idiopathic Granulomatous Mastitis (IGM).
- To clarify the relationship between lifestyle, medical history, and IGM development.
Main Methods:
- A multi-center prospective case-control study involving 504 IGM patients and 504 controls.
- Data collected by trained staff; analyzed using multivariate binary logistic regression.
Main Results:
- Previous breastfeeding history showed a 7-fold increased risk of IGM (OR=7.51).
- History of diabetes was a significant risk factor (OR=4.23).
- Oral contraceptive pill (OCP) use demonstrated a protective effect (OR=0.70).
Conclusions:
- Breastfeeding history, not duration, is linked to increased IGM rates.
- Diabetes history is a confirmed risk factor for IGM.
- OCP use appears to be a protective factor against IGM.
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