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Updated: May 12, 2025

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

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T Cell Aging: An Important Target for Perioperative Immunomodulation.

Haoning Lan¹, Songchao Xu¹, Huili Li¹

¹Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Clinical Interventions in Aging

|May 7, 2025

Summary

This summary is machine-generated.

T cell aging is impacted by perioperative complications, affecting patient recovery. Identifying high-risk individuals and employing interventions like prehabilitation can improve outcomes.

Keywords:

CD57 T cell aging immunomodulation perioperative period senescence-associated secretory phenotype terminal effector memory T cells

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Area of Science:

Immunology
Gerontology
Anesthesiology

Background:

T cells are vital for immune function, but their roles and aging processes change significantly with age.
Perioperative pain and stress can compromise immune status, impacting patient recovery.
T cell aging is a distinct process with clinical indicators, influenced by various health factors.

Purpose of the Study:

To examine how preoperative and intraoperative complications influence T cell aging.
To identify patient groups at high risk for perioperative T cell aging.
To discuss the impact of T cell aging on postoperative outcomes and potential interventions.

Main Methods:

Review and analysis of existing literature on T cell aging.
Identification of various preoperative and intraoperative factors influencing T cell aging.
Discussion of clinical indicators and potential therapeutic strategies.

Main Results:

Numerous factors, including chronic diseases (hypertension, diabetes), acute conditions (ARDS, hypoxemia), psychological states (depression), pain, obesity, neurological and autoimmune diseases, anesthetic choices, surgical types, and medications, can affect T cell aging.
Elderly cancer patients with multiple comorbidities are identified as a high-risk group for perioperative T cell aging.
T cell aging is linked to postoperative neurological dysfunction and reduced recovery quality.

Conclusions:

Preoperative and intraoperative complications significantly influence T cell aging.
Targeted interventions such as prehabilitation, pharmacological treatments, and adoptive neuro-immunotherapy show promise in modulating T cell aging.
Modulating T cell aging during the perioperative period may enhance clinical prognosis and improve patient recovery.