T Cell Aging: An Important Target for Perioperative Immunomodulation.
Haoning Lan1, Songchao Xu1, Huili Li1
1Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
Clinical Interventions in Aging
|May 7, 2025
Summary
T cell aging is impacted by perioperative complications, affecting patient recovery. Identifying high-risk individuals and employing interventions like prehabilitation can improve outcomes.
Area of Science:
- Immunology
- Gerontology
- Anesthesiology
Background:
- T cells are vital for immune function, but their roles and aging processes change significantly with age.
- Perioperative pain and stress can compromise immune status, impacting patient recovery.
- T cell aging is a distinct process with clinical indicators, influenced by various health factors.
Purpose of the Study:
- To examine how preoperative and intraoperative complications influence T cell aging.
- To identify patient groups at high risk for perioperative T cell aging.
- To discuss the impact of T cell aging on postoperative outcomes and potential interventions.
Main Methods:
- Review and analysis of existing literature on T cell aging.
- Identification of various preoperative and intraoperative factors influencing T cell aging.
- Discussion of clinical indicators and potential therapeutic strategies.
Main Results:
- Numerous factors, including chronic diseases (hypertension, diabetes), acute conditions (ARDS, hypoxemia), psychological states (depression), pain, obesity, neurological and autoimmune diseases, anesthetic choices, surgical types, and medications, can affect T cell aging.
- Elderly cancer patients with multiple comorbidities are identified as a high-risk group for perioperative T cell aging.
- T cell aging is linked to postoperative neurological dysfunction and reduced recovery quality.
Conclusions:
- Preoperative and intraoperative complications significantly influence T cell aging.
- Targeted interventions such as prehabilitation, pharmacological treatments, and adoptive neuro-immunotherapy show promise in modulating T cell aging.
- Modulating T cell aging during the perioperative period may enhance clinical prognosis and improve patient recovery.
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