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Relationship Between Depression and Medication Adherence in Older Patients With Cardiovascular Disease: A Systematic

Mina Berimavandi1, Parvin Abbasi2, Behnam Khaledi-Paveh3

  • 1Student Research Committee Kermanshah University of Medical Sciences Kermanshah Iran.

Health Science Reports
|May 7, 2025
PubMed

Insights

Depression significantly impacts medication adherence in older adults with cardiovascular disease (CVD). Addressing depression is crucial for improving treatment compliance and health outcomes in this population.

Area of Science:

  • Gerontology
  • Cardiology
  • Psychiatry

Background:

  • Cardiovascular disease (CVD) and depression are leading global causes of disability.
  • Medication adherence is critical for CVD patient outcomes.
  • Depression negatively affects medication compliance in CVD patients.

Purpose of the Study:

  • To investigate the association between depression and medication adherence in elderly patients diagnosed with CVD.

Main Methods:

  • Systematic literature search across eight major databases up to December 2021.
  • Risk of bias assessment using the Joanna Briggs Institute scale.
  • Meta-analysis conducted using a random effects model and CMA 2 software.

Main Results:

  • Seven studies involving 10,153 elderly CVD patients were analyzed.
  • A significant inverse relationship was found between depression and medication adherence.
  • Depression was associated with a 40% reduction in medication adherence (OR 0.603).

Conclusions:

  • Depression substantially reduces medication adherence in older adults with CVD.
  • Further primary research is recommended to confirm these findings.
  • Integrated care addressing both depression and adherence is vital for CVD management.
Abstract

Keywords:
agedcardiovasculardepressionmedication adherence

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