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Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease

Cong-Cong Ding1,2,3, Xiao Huang1,2,3,4, Hui-Hui Bao1,2,3,4

  • 1Department of Cardiovascular Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|May 7, 2025
PubMed

Insights

Chronic kidney disease (CKD) patients often have high homocysteine levels, increasing cardiovascular risks. While B vitamins lower homocysteine, their impact on CKD progression and complications needs further research.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Patients with chronic kidney disease (CKD) exhibit significantly higher rates of cardiovascular events and mortality compared to the general population.
  • Impaired renal function in end-stage CKD leads to hyperhomocysteinemia (HHcy) in approximately 85% of cases.
  • The precise role of HHcy in CKD pathogenesis versus its function as a mere biomarker remains unclear.

Purpose of the Study:

  • To review current research on the association between HHcy and CKD.
  • To explore the potential of HHcy as a therapeutic target in CKD management.
  • To provide insights into novel prevention and treatment strategies for CKD and its cardiovascular complications.

Main Methods:

  • Literature review of recent studies.
  • Analysis of research on the relationship between homocysteine levels and CKD progression.
  • Evaluation of the efficacy of B vitamin supplementation in CKD patients with HHcy.

Main Results:

  • HHcy is a common comorbidity in CKD patients, linked to increased cardiovascular risk.
  • B vitamin supplementation (folic acid, B6, B12) effectively reduces plasma homocysteine levels.
  • The impact of HHcy reduction on slowing CKD progression and preventing cardiovascular complications is not definitively established.

Conclusions:

  • HHcy is a significant factor in CKD patients, associated with poor cardiovascular outcomes.
  • Further research is needed to clarify the therapeutic benefits of targeting HHcy in CKD.
  • Novel strategies are required for effective prevention and treatment of CKD and associated cardiovascular diseases.

Keywords:
chronic kidney diseasefolic acidhomocysteinehyperhomocysteinemiavitamin

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