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Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs
Jia-Hua Zhao1,2, Xiao-Sa Yang2,3, Xiao-Jiao Xu1,2
1School of Medicine,Nankai University,Tianjin 300071,China.
Abstract:
P-glycoprotein(P-gp)is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cell to the outside of the cell to maintain a stable endo-environment.However,it meanwhile restricts the entry of therapeutic drug into tissues and organs,and in particular,mediates the multidrug resistance of tumor cells to chemotherapeutic drugs.Therefore,understanding the localization of P-gp in different tissues and organs may be an important breakthrough point for disease treatment.In this paper,we mainly review the molecular structure,transport mechanism,localization,and regulation of P-gp in different tissues and organs,providing reference for the subsequent treatment of diseases.
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