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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

245
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
245
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

272
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
272
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

309
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
309
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

329
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
329
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

175
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
175
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

1.7K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Related Experiment Video

Updated: May 8, 2025

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Recent Trends in Drug Delivery Systems.

Omnia Mohamed Sarhan1

  • 1Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Badr University in Cairo (BUC), Cairo, Egypt.

Assay and Drug Development Technologies
|May 7, 2025
PubMed
Summary

Nanotechnology enhances drug delivery systems for improved cancer therapy. Various nanocarriers precisely target tumors, increasing medication effectiveness and reducing side effects for better patient outcomes.

Keywords:
dendrimershexagonal boron nitride nanosheethyaluronic acidmesoporous silicapolymer-lipid hybrid nanoparticlesquantum dots

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Drug delivery systems are evolving with nanotechnology for enhanced therapeutic efficacy.
  • Hyaluronic acid-based nanocarriers are prominent in cancer therapy for targeted drug delivery.

Purpose of the Study:

  • To review advancements in nanotechnology-integrated drug delivery systems.
  • To highlight various nanocarriers and their roles in improving drug administration and patient outcomes.

Main Methods:

  • Review of diverse nanotechnologies including quantum dots, carbon nanotubes, dendrimers, mesoporous silica nanoparticles, polymer-lipid hybrid nanoparticles, and hexagonal boron nitride nanosheets.
  • Analysis of their properties for drug transport, targeting, and release modulation.

Main Results:

  • Nanocarriers like quantum dots offer precise monitoring, while carbon nanotubes allow controlled drug release.
  • Dendrimers and polymer-lipid hybrids enhance drug loading and bioavailability.
  • Mesoporous silica and hexagonal boron nitride nanosheets enable tailored release rates and biocompatible administration.

Conclusions:

  • Nanotechnology addresses challenges in drug delivery, such as poor bioavailability and adverse effects.
  • These advancements significantly improve therapeutic efficacy and patient outcomes in cancer treatment.
  • Future research will expand therapeutic applications of these nanotechnologies.