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Causal relationship between educational attainment and Hashimoto's thyroiditis: a two-sample mendelian randomization

Rongjia Zhang1, Yulu Chen2, Xian Deng3

  • 1Department of Thyroid Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, China. zhangrongjia930215@163.com.

Endokrynologia Polska
|May 7, 2025
PubMed
Summary

Higher educational attainment (EA) is genetically linked to a reduced risk of developing Hashimoto

Keywords:
Hashimoto’s thyroiditiseducational attainmentmendelian randomization

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Area of Science:

  • Genetics
  • Epidemiology
  • Endocrinology

Background:

  • Hashimoto's thyroiditis (HT) has a complex etiology.
  • A correlation exists between educational attainment (EA) and overall health.
  • This study investigates the genetic link between EA and HT.

Purpose of the Study:

  • To explore the causal relationship between educational attainment and Hashimoto's thyroiditis using genetic data.
  • To apply Mendelian randomization to assess the impact of EA on HT risk.

Main Methods:

  • Utilized summary data from the MRC IEU Open GWAS database for EA and HT.
  • Employed two-sample Mendelian randomization (TSMR) with various methods (IVW, MR-Egger, weighted median, etc.).
  • Assessed heterogeneity and pleiotropy using Cochran's Q test, MR-Egger intercept, and MR-PRESSO.

Main Results:

  • A significant inverse association was found between EA and HT risk (OR: 0.933, p < 0.001) via IVW.
  • The weighted median method corroborated this finding (OR: 0.938, p = 0.029).
  • No significant heterogeneity or pleiotropy was detected, indicating robust results.

Conclusions:

  • Higher educational attainment is genetically associated with a lower risk of Hashimoto's thyroiditis.
  • This genetic correlation suggests a protective effect of EA on HT development.