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Updated: Apr 26, 2026

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Published on: June 9, 2023
Association between thyroid disorders and the Risk of developing prostate cancer: A systematic review and
Daniel Andrés Nieva-Posso1,2, Valeria Perea Ocampo1, Daniel Alfonso Nieva Posso3
1UROGIV Research Group, School of Medicine, Universidad del Valle, Cali, Colombia.
Objective:
To determine the association between thyroid disorders and the Risk of developing prostate cancer.
Methods:
We conducted this review following the recommendations of the Cochrane Collaboration and the PRISMA Statement. From the moment to the present, we have conducted a search strategy using MEDLINE, WEB OF SCIENCE, and GOOGLE SCHOLAR. We included cohort and case-control studies that examined the relationship between thyroid disorders and the Risk of developing prostate cancer. We assessed the Risk of bias using the Newcastle Ottawa Quality Assessment scale. Meta-analysis was conducted in Review Manager 5.4.1 (Revman®).
Results:
We included nine studies in the analysis. The studies included were classified into two groups: those that studied hypothyroidism and those that studied hyperthyroidism. The results showed no association between thyroid abnormalities and prostate cancer risk, with an HR of 1.05 (95% CI: 0.90-1.22). Hyperthyroidism also showed no association with an HR 1.64 (95% CI: 1.00-2.69), characterized by increased serum T4 and decreased TSH. There was also no significant association with hypothyroidism, with an HR of 0.85 (95% CI: 0.67-1.10).
Conclusion:
Thyroid disorders were not associated with the Risk of developing prostate cancer.
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