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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

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Related Experiment Video

Updated: Jun 29, 2026

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
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Refillable Intraocular Drug-Eluting Implant.

Hyeonji Kim1, Nae-Won Kang1, Roger Wise2

  • 1Department of Ophthalmology, Byers Eye Institute at Stanford University, School of Medicine, Palo Alto, California 94304, United States.

ACS Applied Materials & Interfaces
|May 7, 2025
PubMed
Summary
This summary is machine-generated.

A new refillable implant offers long-term eye disease management, overcoming challenges of frequent eye drops and injections. This device improves drug delivery, patient compliance, and therapeutic outcomes for ophthalmic conditions.

Keywords:
cataract surgerydrug delivery systemintraocular implantocular treatmentsustained release

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • Ophthalmic diseases necessitate frequent medication, leading to poor patient compliance and discomfort.
  • Current drug delivery methods like eye drops and intravitreal injections have limitations including poor bioavailability and short drug half-life.

Purpose of the Study:

  • To introduce a novel, refillable intracapsular drug-eluting reservoir for sustained ophthalmic drug delivery.
  • To evaluate the device's material properties, implantation feasibility, and drug release characteristics.

Main Methods:

  • Rheological and mechanical analyses were performed on medical-grade silicone and stainless steel components.
  • In vitro drug release studies were conducted to determine release kinetics.
  • Ex vivo implantation tests were performed during simulated cataract surgery.

Main Results:

  • Optimized conditions for device construction and ocular implantation compliance were identified.
  • The device demonstrated controlled drug release following Fickian diffusion kinetics.
  • Successful and easy delivery and placement of the implant during ex vivo surgery were confirmed.

Conclusions:

  • The developed intracapsular drug-eluting reservoir offers a promising solution for long-term ophthalmic disease management.
  • The implant design facilitates microincisional implantation and enhances patient compliance.
  • This novel device has significant potential to improve therapeutic outcomes in ocular treatments.