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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: May 12, 2025

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
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Kinase-Targeted Therapies for Glioblastoma.

Maria Salbini1, Alessia Formato1, Maria Patrizia Mongiardi1

  • 1Institute of Biochemistry and Cell Biology, National Research Council, Via Ercole Ramarini 32, Monterotondo, 00015 Rome, Italy.

International Journal of Molecular Sciences
|May 7, 2025
PubMed
Summary

Kinase inhibitors are crucial for treating glioblastoma, a deadly brain cancer. This review examines the history and development of these targeted therapies for glioblastoma patients.

Keywords:
glioblastomakinase inhibitortherapy

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Protein phosphorylation by kinases and phosphatases regulates cellular functions.
  • Dysregulated kinase activity is linked to cancer, particularly glioblastoma.
  • Receptor tyrosine kinase (RTK) pathway mutations are common in glioblastoma.

Purpose of the Study:

  • To review the history of kinase inhibitor drugs in glioblastoma therapy.
  • To highlight the role of targeted therapies in treating this aggressive brain tumor.

Main Methods:

  • Literature review of kinase inhibitors and glioblastoma treatment.
  • Analysis of historical data on drug development and approval.
  • Examination of signaling pathways implicated in glioblastoma.

Main Results:

  • Kinase inhibitors represent a significant advancement in glioblastoma treatment.
  • Regorafenib, a multi-kinase inhibitor, has recently gained approval for glioblastoma.
  • Targeted therapies aim to address RTK pathway dysregulation.

Conclusions:

  • Kinase inhibitors have evolved as a vital therapeutic strategy for glioblastoma.
  • Further research into kinase inhibitor mechanisms and combinations is warranted.
  • Understanding the history of these drugs informs future glioblastoma treatment approaches.