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Updated: May 12, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Published on: April 5, 2018

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Chromoplexy: A Pathway to Genomic Complexity and Cancer Development

Franck Pellestor1, Benjamin Ganne1, Jean Baptiste Gaillard1

  • 1Chromosomal Genetics Unit and Chromostem Research Platform, Department of Molecular Genetics and Cytogenomics, Unique Site of Biology (SUB), University Hospital of Montpellier, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.

International Journal of Molecular Sciences
|May 7, 2025
PubMed
Summary

Chromoplexy causes complex rearrangements across multiple chromosomes in a single cell event. This genomic instability, seen in various cancers, drives tumor evolution and progression.

Keywords:
chromoanagenesischromoplexydeletiongene fusionprostate cancerpunctuated evolutiontranslocationtumor

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