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MXene-based nanocomposites: synthesis, optical properties, and biomedical applications
Hui Huang1, Jian Zhu2, Guojun Weng1
1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Mikrochimica Acta
|May 7, 2025
Summary
MXene-based nanocomposites show great promise for biomedical applications due to their unique properties. This review details their synthesis, optical characteristics, and uses in biosensing, therapy, and imaging.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Two-dimensional (2D) carbide/nitride MXenes have emerged as novel materials with unique properties.
- MXene-based nanocomposites exhibit synergistic effects, enhancing their potential for diverse applications.
- The biomedical field is exploring MXene nanocomposites for advanced functionalities.
Purpose of the Study:
- To provide a comprehensive review of MXene-based nanocomposites for biomedical applications.
- To discuss synthesis strategies, optical properties, and key applications.
- To identify future challenges and opportunities in the field.
Main Methods:
- Review and synthesis of existing literature on MXene-based nanocomposites.
- Categorization of synthesis methods based on surface engineering and properties.
- Summary of optical properties including localized surface plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and photothermal conversion efficiency (PCE).
Main Results:
- Various synthesis methods for MXenes and their nanocomposites are discussed and compared.
- Optical properties like LSPR, SERS, and PCE are summarized.
- Applications in biosensors, optical therapeutics, and bioimaging are detailed.
Conclusions:
- MXene-based nanocomposites offer significant potential for advanced biomedical applications.
- Further research is needed to address challenges and unlock future opportunities.
- Development of high-performance MXene nanocomposites is crucial for clinical translation.

