First-in-Human Linear Magnetic Jejuno-Ileal Bipartition: Preliminary Results with Incisionless, Sutureless,...

Area of Science:

• Minimally invasive surgery
• Gastroenterology
• Bariatric surgery

Background:

• Novel biofragmentable magnetic anastomosis compression system for minimally invasive surgery.
• Magnetic jejuno-ileostomy (MagJI) bipartition for weight and type 2 diabetes (T2D) reduction.
• MagJI reduces complications associated with traditional enterotomy, stapling, and suturing.

Purpose of the Study:

• Evaluate the feasibility, safety, and preliminary efficacy of the MagJI procedure.
• Assess weight and T2D reduction in adults with obesity.

Main Methods:

• Prospective first-in-human investigation in adults with BMI 30.0-40.0.
• Introduction of magnets via swallowing or endoscopy, guided laparoscopically.
• Laparoscopic alignment of magnets in the distal ileum and proximal jejunum, with fusion over 7-21 days.

Main Results:

• Nine patients (mean BMI 37.3) with T2D underwent MagJI.
• 100% 90-day feasibility with 0% bleeding, leakage, infection, or mortality.
• Significant reduction in BMI, HbA1c, and T2D medications at 6 months.

Conclusions:

• Swallowable, biofragmentable magnetic anastomosis system is feasible and safe for incisionless, sutureless jejuno-ileostomy.
• First-in-human MagJI procedure offers a less complicated anastomosis creation.
• MagJI demonstrates potential for moderate weight loss and T2D reduction.