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Cannabinoids: Adaptogens or Not?

Federico Karp1, Ignacio E León2,3

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This review compares cannabinoids (CNBs) and adaptogens, exploring their potential classification together. It examines their biological effects, stress resistance, and homeostasis capabilities for potential therapeutic overlap.

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Area of Science:

  • Pharmacology and Natural Product Chemistry
  • Neurobiology and Physiology
  • Integrative Medicine

Background:

  • Humanity has historically sought natural substances to enhance stress resistance and homeostasis.
  • Adaptogens and cannabinoids (CNBs) are natural compounds with potential therapeutic applications.
  • The classification of CNBs alongside adaptogens remains a subject of scientific inquiry.

Purpose of the Study:

  • To compare the biological effects of cannabinoids (CNBs) with adaptogens.
  • To explore the scientific basis for potentially classifying CNBs as adaptogens.
  • To analyze the properties of CNBs and adaptogens concerning stress resistance and homeostasis.

Main Methods:

  • Review of adaptogen features: chemical structure, ligand-receptor interactions, and stress-coping mechanisms.
  • Overview of preclinical and clinical studies on adaptogen effects against diverse stressors.
  • Comprehensive review of CNBs' effects on the body and the endocannabinoid system.

Main Results:

  • Adaptogens exhibit stress-resistance and homeostasis-enhancing properties.
  • CNBs demonstrate a wide range of effects, with therapeutic potential for various diseases.
  • The endocannabinoid system mediates many of the body-wide effects of CNBs.

Conclusions:

  • Comparative analysis suggests potential overlap in biological effects between CNBs and adaptogens.
  • Further research is needed to definitively classify cannabinoids within the adaptogen category.
  • Understanding these properties could inform novel therapeutic strategies for stress-related conditions.