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Updated: May 15, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
[Negative affectivity in new mothers during the COVID-19 lockdown]
Alma Patricia González1, Diana Gabriela Camacho-Osuna1, Raymundo López-Martínez2
1Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Gineco Pediatría No. 48, Dirección de Educación e Investigación en Salud. León, Guanajuato, México.
Background:
Confinement due to health emergencies such as the coronavirus disease 19 (COVID-19) creates additional challenges for pregnant women (PW), negatively influencing their mental health.
Objective:
To evaluate the presence of symptoms suggestive of depression (SSD), anxiety (SSA), and stress (SSS) and associated factors in PW during confinement due to the COVID-19 pandemic.
Material And Methods:
Analytical and prolific prevalence study carried out in hospitalized primigravidae PW, aged 14 to 41 years. Clinical, psychosocial, and sociodemographic data from the PM and medical records were collected, and the DASS-21 questionnaire was administered. Chi-square or Fisher's exact test, odds ratio (OR), and logistic regression were used.
Results:
232 PW with a median age of 23 years (20-27) were included. The incidence of SSD was 37.07%, SSA 45.69%, SSS 35.78%. Risk factors for SSD were not having a partner: OR 2.12 (95% CI 1.15-3.93), p = 0.01, and having low socioeconomic status 3.06 (95% CI 1.70-5.49), p = 0.0001. In SSA, unemployment was 1.76 (1.04-2.96), p = 0.03. And for SES, basic education showed 0.49 (95% CI 0.28-0.88), p = 0.01, low socioeconomic status 1.80 (95% CI 1.01-3.22), p = 0.04, and comorbidities 2.15 (95% CI 1.04-4.44), p = 0.03.
Conclusion:
During the COVID-19 lockdown, the frequency of SSD, SSA and SSS in primigravidae PW was high, and associated factors were not having a partner, low socioeconomic status, unemployment, and comorbidities.
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