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Updated: May 13, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Comment on the article "Erythrocyte morphological alterations as predictors of kidney injury severity"]
1Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Servicio de Nefrología. Ciudad de México, México.
Abstract:
After reviewing the article "Erythrocyte morphological alterations as predictors of kidney injury severity" published by Cruz-Balbuena et al., we can emphasize that erythrocytic changes have several pathophysiological mechanisms, such as iron deficiency, vitamin B12 deficiency, and the pro-inflammatory state of chronic kidney disease (CKD) itself. Furthermore, due to the accumulation of uremic toxins that result in a shortened lifespan of erythrocytes, a selection bias was found in their population and a positive but non-linear correlation. There are already several well-established progression markers with better correlation.
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