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Updated: May 14, 2025

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
Host Genetic Factors in Q Fever Susceptibility
José-María Robaina Bordón1,2, José-Luis Pérez-Arellano3, Olga Montes-Ares4
1Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, Spain.
Abstract:
Several indirect findings suggest that host-related factors influence susceptibility to Coxiella burnetii infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.
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