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Updated: May 12, 2025

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
Published on: December 22, 2023
Phytotoxicity, Cytotoxicity, and Antimicrobial Activity of Triethanolammonium Amino Acids Salts
Barbara Hanna Roman1, Magdalena Charęza2, Radosław Drozd2
1Department of Organic Chemical Technology and Polymer Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Pułaskiego 10, 70-322 Szczecin, Poland.
Abstract:
The growing use of ionic liquids (ILs) necessitates an understanding of their environmental impact and toxicity levels. In this study, a series of amino acid-based ionic liquids containing the triethanolammonium (TEA) cation were evaluated for their biological activity against Lepidium sativum L., the mouse fibroblast cell line L929, a selection of gram-positive and gram-negative bacteria, and the yeast Candida albicans. The influence of amino acid anion structure on toxicity was also examined. Among the tested ionic liquids, [TEA][Asp] exhibited low toxicity toward Lepidium sativum L., representing terrestrial plants, while [TEA][Phe] showed the lowest cytotoxicity. Regarding microbial activity, [TEA][Lys] demonstrated greater bactericidal effectiveness against E. coli than S. aureus, while both [TEA][Lys] and [TEA][Arg] exhibited the strongest inhibitory effect against C. albicans. Our findings underscore the crucial role of IL salt composition in determining biological activity, highlighting the significance of interactions between IL components in shaping their potential effects.
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