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Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An
Adriana Gargano1,2, Ilario Greco1,2, Carmine Lupia3,4
1Dipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.
Abstract:
Cancer is the second leading cause of death in the world, with scientific evidence indicating that the enzymes aromatase and cyclooxygenase 2 are upregulated in several types of cancer. Over the past 30 years, natural compounds have played a crucial role in cancer chemotherapy, and to date, many phytocompounds have been reported to interact with these enzymes, inhibiting their activity. Notably, several phytocompounds found in Rosmarinus officinalis L., a medicinal plant native to the Mediterranean region and cultivated around the world, have shown the ability to interact with these enzymes. This review examines the role of the main compounds contained in Rosmarinus officinalis L. as potential anticancer agents acting on aromatase and cyclooxygenase-2.
Insights
This review explores Rosmarinus officinalis L. compounds as potential anticancer agents. These natural compounds may inhibit key enzymes, aromatase and cyclooxygenase-2, often upregulated in various cancers.
Area of Science:
- Pharmacology and Oncology
- Natural Product Chemistry
Background:
- Cancer is a leading global cause of death.
- Aromatase and cyclooxygenase-2 (COX-2) enzymes are frequently upregulated in numerous cancer types.
- Natural compounds, particularly phytocompounds, have a significant history in cancer chemotherapy, often by interacting with key enzymes.
Purpose of the Study:
- To review the role of main compounds from Rosmarinus officinalis L. as potential anticancer agents.
- To investigate the interaction of these phytocompounds with aromatase and COX-2 enzymes.
Main Methods:
- Literature review of scientific evidence on Rosmarinus officinalis L. compounds.
- Analysis of studies reporting the interaction of phytocompounds with aromatase and COX-2.
- Focus on compounds within Rosmarinus officinalis L.
Main Results:
- Rosmarinus officinalis L. is rich in phytocompounds with demonstrated enzyme-inhibiting properties.
- Several compounds from this medicinal plant show potential for interacting with and inhibiting aromatase and COX-2.
- These interactions suggest a role in anticancer activity.
Conclusions:
- Compounds from Rosmarinus officinalis L. show promise as natural anticancer agents.
- Targeting aromatase and COX-2 with these phytocompounds represents a potential therapeutic strategy.
- Further research into Rosmarinus officinalis L. for cancer treatment is warranted.
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