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Lead-Structure-Based Rigidization Approach to Optimize SirReal-Type Sirt2 Inhibitors

Matthias Frei1, Thomas Wein1, Franz Bracher1

  • 1Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany.

Molecules (Basel, Switzerland)
|May 7, 2025
PubMed
Summary

Researchers developed novel Sirt2 inhibitors using a rigidization strategy. The naphthalene derivative FM69 shows high potency, offering a promising foundation for cancer and neurodegenerative disease research.

Keywords:
SirReal2Sirt2 inhibitorrigidizationsirtuin 2 inhibitorstructure–activity relationship

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