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Updated: May 12, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide
MaryGrace McAfee1, Joshua Pack1, Brian Walker1
1Department of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave Science Lab Building 451, Little Rock, AR 72204, USA.
Abstract:
A solvent-free, microwave-assisted approach for the ring-opening reactions of phenyl glycidyl ether with a series of commercially available imidazoles and pyrazoles is described. Microwave irradiation allows reactions to proceed rapidly. This straightforward approach efficiently generated adducts with competitive yields compared to traditional methods that use conventional heating or organic solvents. This technique is particularly suited for high-throughput screening in drug discovery, offering a significant reduction in time and resource consumption.
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