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Research Progress on the Structure-activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of

Jiacheng Yao1,2, Feng Zhu3, Yikun Feng1,2

  • 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Molecules (Basel, Switzerland)
|May 7, 2025
PubMed

Insights

New flavonoid derivatives show promise for treating non-small-cell lung cancer (NSCLC). Structurally optimized flavonoids offer enhanced anticancer activity and improved properties, addressing limitations of current NSCLC therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Non-small-cell lung cancer (NSCLC) is a leading cause of cancer mortality globally.
  • Current NSCLC treatments face challenges due to late diagnosis, metastasis, severe side effects, and drug resistance.
  • There is a critical need for novel NSCLC therapeutics with improved efficacy and reduced toxicity.

Purpose of the Study:

  • To review the mechanisms of action of flavonoid derivatives against NSCLC.
  • To explore the structure-activity relationships (SARs) of these compounds.
  • To provide a scientific basis for developing new flavonoid-based NSCLC drugs.

Main Methods:

  • Literature review of studies on flavonoid derivatives and NSCLC.
  • Analysis of reported mechanisms of action, including cellular and molecular targets.
  • Examination of SAR data to identify key structural features for anticancer activity.

Main Results:

  • Flavonoid derivatives exhibit diverse anticancer mechanisms relevant to NSCLC.
  • Structural modifications can significantly enhance the potency and pharmacokinetic profiles of flavonoids.
  • Specific structural features are correlated with improved efficacy and overcoming resistance.

Conclusions:

  • Flavonoid derivatives represent a promising class of compounds for NSCLC treatment.
  • Understanding SARs is crucial for designing effective and targeted flavonoid-based therapies.
  • Further research into optimized flavonoid structures could lead to next-generation NSCLC drugs.
Keywords:
anti-tumor mechanismderivateflavonoidslung cancernatural productsstructure–activity relationships

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