Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.

Cycloaddition Reactions: MO Requirements for Thermal Activation

Cycloaddition Reactions: MO Requirements for Thermal Activation

Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.

Cycloaddition Reactions: Overview

Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...

Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration

Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration

Introduction
Analogous to alkenes, alkynes also undergo acid-catalyzed hydration. While the addition of water to an alkene gives an alcohol, hydration of alkynes produces different products such as aldehydes and ketones.

Formation of Halohydrin from Alkenes

Formation of Halohydrin from Alkenes

An alkene, such as propene, reacts with bromine in the presence of water to yield a halohydrin. Halohydrins contain a halogen and a hydroxyl group attached to adjacent carbons. When the halogen is bromine, it is called a bromohydrin, while a chlorohydrin has chlorine as the halogen.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Supramolecular liquid-liquid extraction enabled by Cy<sub>2</sub>Q[6] for highly selective separation of benzene/cyclohexane mixtures.

RSC advances·2026

Same author

Lipopolysaccharide hydrolysis-targeting nano-chimeras detoxify endotoxin through specific adsorption and efficient degradation.

Nature communications·2026

Same author

Adaptive Cavity-Enabled Crystalline Chirality in Nanocarbon Cages.

Angewandte Chemie (International ed. in English)·2026

Same author

A Self-Assembled Cage Binds Xenon via Xe-F Dispersion Interactions.

Journal of the American Chemical Society·2026

Same author

Synthesis and guest inclusion for molecular catcher-based structure determination.

Nature protocols·2026

Same author

Precise borylation of targeted methyl group via an orderly chain-walking strategy.

Science advances·2026

Search research articles

Related Experiment Video

Updated: May 17, 2025

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

Self-Sorting via Macrocyclization by External Templation in Water.

Yang Liu¹, Yongwei Qian¹, Liya Chen¹

¹Department of Chemistry, Zhejiang University, Hangzhou 310058, China.

Organic Letters

|May 7, 2025

Summary

This summary is machine-generated.

Researchers self-assembled ultrasized macrocycles using bisformyl and bishydrazide precursors in water. Templating with cucurbiturils (CB[8], CB[10]) enabled complex ring-in-ring and ternary structures, demonstrating selective self-sorting.

More Related Videos

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Related Experiment Videos

Last Updated: May 17, 2025

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Area of Science:

Supramolecular Chemistry
Organic Synthesis
Materials Science

Background:

Supramolecular chemistry focuses on the study of complex chemical systems held together by non-covalent interactions.
Macrocycles are large ring structures that are of interest in various fields, including host-guest chemistry and materials science.
Cucurbiturils (CBs) are macrocyclic hosts known for their ability to bind guests through hydrophobic and electrostatic interactions.

Purpose of the Study:

To synthesize ultrasized macrocycles through a self-assembly process.
To investigate the templating effects of cucurbiturils (CB[8] and CB[10]) on macrocycle formation.
To explore the self-sorting behavior of multiple precursors in a single reaction vessel.

Main Methods:

Condensation reactions between bisformyl precursors and bishydrazide partners in water.
Utilizing cucurbit[8]uril (CB[8]) as an external template for ring-in-ring complex formation.
Employing cucurbit[10]uril (CB[10]) and a π-electron-rich guest as dual templates for ternary complex assembly.
Mixing all seven precursors to observe self-sorting phenomena.

Main Results:

Successful self-assembly of two distinct ultrasized macrocycles in aqueous solution.
Formation of a ring-in-ring complex using CB[8] as a template.
Construction of a ternary "Russian doll" complex with CB[10] and a π-electron-rich guest.
Demonstration of selective self-sorting when all seven precursors were combined, yielding no hybridized products.

Conclusions:

Ultrasized macrocycles can be efficiently synthesized via water-based condensation and templated self-assembly.
Cucurbiturils act as effective templates for controlling the architecture of complex supramolecular assemblies.
The system exhibits high fidelity in self-sorting, allowing for the selective formation of desired macrocyclic structures even in the presence of multiple components.