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Updated: May 12, 2025
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the
Chaofan Geng1, Peiyang Gao1, Yi Tang2
1Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Background:
Metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention for its potential link with dementia. This study aims to investigate the association between MAFLD and dementia, including its subtypes, to address existing knowledge gaps.
Methods:
A total of 415,116 participants from the UK Biobank were included, with standardized screening criteria used to determine MAFLD diagnosis. Cox regression was employed to assess the relationship between MAFLD and dementia risk. Subgroup analyzes were conducted to provide further insights into the impact of MAFLD on dementia risk, and the mediation effect of inflammation was evaluated.
Results:
Among the 150,509 MAFLD patients, there was a significantly elevated risk of dementia, with hazard ratios (HR) of 1. 526 (95 % CI = 1. 460-1. 596) for all-cause dementia, 1. 356 (95 % CI = 1. 266-1. 453) for Alzheimer's disease (AD), and 2. 206 (95 % CI = 2. 000-2. 434) for vascular dementia (VaD). MAFLD patients showed a significant reduction in gray matter volume in MAFLD patients (β = -0. 07, 95 % CI = -0. 17, -0. 01) and a marked increase in deep white matter lesion volume (P < 0. 001). Elevated inflammatory markers in MAFLD patients accounted for a mediation effect of 30. 8 %.
Conclusion:
MAFLD substantially increases the risk of dementia, underscoring the importance of early intervention and prevention strategies targeting MAFLD to reduce dementia incidence.
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