Cell biology of astrocytic adhesive interactions and signaling pathways in regulating neuronal circuits

Astrocytes have attracted attention for their crucial roles in various brain functions. Yet a gap remains in our understanding. The cellular and molecular basis by which astrocytes interact with neuronal circuits are not clear, and how astrocytes leverage their hallmark morphology dominated by intricate processes in implementing their functions require consideration. This review highlights insights into these outstanding questions gained from recent studies featuring mediators and regulators of cell-cell interactions between astrocytes and neurons, focusing on cell adhesion proteins such as cadherins and neuroligins, among others, as well as cell-extracellular matrix interactions, including astrocytic interactions with the perineuronal network.