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Characterization and Functional Prediction of Bacteria in Ovarian Tissues
Published on: October 23, 2021
Microbiota mechanisms in cancer progression and therapy
Xing Zhang1, Kyong Tkhe Fam1, Tingting Dai1
1Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA.
None:
The composition of the microbiota in patients has been shown to correlate with cancer progression and response to therapy, highlighting unique opportunities to improve patient outcomes. In this review, we discuss the challenges and advancements in understanding the chemical mechanisms of specific microbiota species, pathways, and molecules involved in cancer progression and treatment. We also describe the modulation of cancer and immunotherapy by the microbiota, along with approaches for investigating microbiota enzymes and metabolites. Elucidating these specific microbiota mechanisms and molecules should offer new opportunities for developing enhanced diagnostics and therapeutics to improve outcomes for cancer patients. Nonetheless, many microbiota mechanisms remain to be determined and require innovative chemical genetic approaches.
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