Related Experiment Video
Updated: May 7, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Uncovering NINJ1 in SLE: Biomarker potential for renal and hematologic manifestations
Muyuan Li1, Ke Liu2, Meidong Liu2
1Department of Rheumatology, Xiangya Hospital, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Sepsis Translational Medicine Key Lab of Hunan Province, Changsha, Hunan, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Objective:
Systemic lupus erythematosus (SLE) is a complex autoimmune disease, with an unclear etiology. This study investigated the clinical relevance of serum NINJ1 levels in SLE and evaluated its potential as a biomarker.
Methods:
Serum NINJ1 levels were measured in 99 newly diagnosed SLE patients and 43 healthy controls. Associations with clinical features, inflammatory markers, and autoantibodies were analyzed. ROC curve analysis was performed for diagnostic evaluation.
Results:
Serum NINJ1 levels were significantly higher in SLE patients (p < 0.0001) and further elevated in those with lupus nephritis (LN) and thrombocytopenia. Positive correlations with proteinuria, CRP, and NLR were found. ROC analysis showed good diagnostic performance (AUC = 0.83).
Conclusion:
Serum NINJ1 is a promising biomarker for SLE, particularly for identifying LN and thrombocytopenia, and may aid in disease stratification and monitoring.
