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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

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Targeting programmed cell death pathways in gastric cancer: a focus on pyroptosis, apoptosis, necroptosis and

Minghui Yao1, Liying Miao1, Xin Wang1

  • 1Department of Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830017, China.

Gene
|May 7, 2025
PubMed

Insights

This review explores programmed cell death (PCD) pathways, including pyroptosis, apoptosis, necroptosis, and PANoptosis, in gastric cancer (GC). Understanding these cell death mechanisms offers new therapeutic targets for this prevalent malignancy.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality worldwide.
  • Programmed cell death (PCD) plays a critical role in cancer progression and treatment.
  • Existing research links pyroptosis, apoptosis, and necroptosis to GC development.

Purpose of the Study:

  • To review the emerging roles of pyroptosis, apoptosis, necroptosis, and PANoptosis in gastric cancer.
  • To identify potential therapeutic targets within these PCD pathways for GC treatment.
  • To provide insights into novel treatment strategies for gastric cancer.

Main Methods:

  • Literature review of studies on PCD and gastric cancer.
  • Analysis of the mechanisms of pyroptosis, apoptosis, necroptosis, and PANoptosis.
  • Synthesis of current understanding of these pathways in GC progression and therapy.

Main Results:

  • PANoptosis, a novel PCD form, shares features with pyroptosis, apoptosis, and necroptosis.
  • These PCD pathways are implicated in various diseases, including cancer.
  • Emerging evidence highlights their significance in gastric cancer.

Conclusions:

  • Targeting pyroptosis, apoptosis, necroptosis, and PANoptosis presents promising therapeutic avenues for gastric cancer.
  • Further research into these PCD signaling pathways can drive the development of innovative GC treatments.
  • Understanding these cell death mechanisms is crucial for advancing gastric cancer therapy.
Keywords:
ApoptosisGastric cancerNecroptosisPANoptosisPyroptosis

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