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Updated: Jun 19, 2026
Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination
Published on: July 4, 2007
Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia
Abdulrahim Hakami1, Ryhanh Tomehi1, Ahmad A Irekeola1
1From the Department of Clinical Laboratory Sciences (Hakami, Alasmari, Makkawi), College of Applied Medical Sciences, King Khalid University, Abha, from the Department of Microbiology and Virology (Tomehi), Abu Arish General Hospital, from the Department of Medical Laboratory Technology (Dobie), Jazan University, from the Department of Hematology and Blood Bank (Matari), Baish General Hospital, Jazan, from the Department of Clinical Laboratory Sciences (Alshehri), College of Applied Medical Sciences; from the Health Research Center (Alshehri), Najran University, Najran, Kingdom of Saudi Arabia, from the Department of Medical Microbiology and Parasitology (Irekeola), School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, from Department of Biological Sciences (Irekeola), Microbiology Unit, College of Natural and Applied Sciences, Summit University Offa, Kwara, Nigeria, and from the Department of Biotechnology (Mohammed), College of Sciences and Technology, Omdurman Islamic University, Omdurman, Sudan.
Objectives:
To analyze hematological parameters for potential predictive markers of dengue.
Methods:
Blood samples were obtained from 146 individuals suspected of having dengue at 2 hospitals in Jazan, Saudi Arabia. Control samples were concurrently collected from healthy adults (n=59). Samples were screened for anti-dengue antibodies by employing enzyme-linked immunosorbent assay. Hematological parameters, such as hemoglobin (HGB), white blood cells, hematocrit (HCT), platelets count, and red blood cells (RBCs) levels were determined for the dengue positive samples and all the controls.
Results:
Of the patients examined, 15% were dengue immunoglobulin M positive and 25% were immunoglobulin G positive. Dengue-infected patients showed lower values of the tested hematological parameters than controls, and significantly lower values were observed for RBCs (p=0.0022), HGB (p=0.0002), and HCT (p<0.0001). Average HGB (12.47g/dl) and HCT (39.03%) values of dengue patients were abnormally low. The average HCT levels were significantly lower in patients with recent dengue infection (41.41% vs. 45.91%, p=0.0230) and past dengue infection (38.63% vs. 45.91%, p<0.0001) compared to controls. However, RBCs and HGB levels were only significantly lower in patients with past and not recent infections.
Conclusion:
The results of this study suggest that prior dengue infections could result in abnormal hematological values, although further research is needed.
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