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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: May 6, 2026

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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EFFICACY OF STEM CELLS IN ENDODONTIC REGENERATION: A SYSTEMATIC REVIEW.

Nausheen Aga1, Scott McGregor2, Sarah Jones1

  • 1School of Dentistry, University of Dundee, Dundee, United Kingdom.

The Journal of Evidence-Based Dental Practice
|May 7, 2025
PubMed
Summary

Stem cell therapy shows promise for regenerating dental pulp in regenerative endodontic procedures (REPs). Further randomized clinical trials are needed to confirm long-term safety and efficacy before widespread use.

Keywords:
Bone-marrow stem cellsDental pulp stem cellsPulp regenerationRegenerative endodonticsRoot canal therapyUmbilical cord stem cells

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Area of Science:

  • Biomedical Engineering
  • Dental Research
  • Regenerative Medicine

Background:

  • Regenerative endodontic procedures (REPs) aim to restore dental pulp vitality and root development.
  • Conventional treatments often fall short in effectively regenerating pulp tissues.
  • This review systematically evaluates stem cell therapy's role in REPs.

Purpose of the Study:

  • To investigate the efficacy of stem cell therapy in regenerative endodontic procedures.
  • To compare stem cell therapy outcomes with conventional endodontic treatments.

Main Methods:

  • A comprehensive electronic search of multiple databases (PubMed, Scopus, CENTRAL, Google Scholar, ClinicalTrials.gov) was performed.
  • Included 1 randomized clinical trial and 18 animal studies evaluating various mesenchymal stem cells (e.g., UCMSCs) and endodontic procedures.
  • Assessed outcomes such as pulpal regeneration, periapical lesion resolution, and tooth vitality restoration.

Main Results:

  • Stem cell therapy demonstrates potential for inducing dental pulp regeneration across various models.
  • Most animal studies reported positive regeneration outcomes, irrespective of stem cell or scaffold type.
  • A clinical trial showed favorable revascularization and reperfusion using UCMSCs with platelet-poor plasma.

Conclusions:

  • Stem cell therapy shows promise for pulp regeneration in REPs.
  • Long-term safety and clinical efficacy require further validation through robust randomized clinical trials.
  • Widespread clinical adoption of stem cell therapy in REPs is pending further evidence.