Related Experiment Video
Updated: May 12, 2025
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
THREE YEARS CLINICAL ASSESSMENT OF LOW CONCENTRATION DIMETHYL SULFOXIDE PRIMER IN NON CARIOUS CERVICAL LESIONS: A
Omar Abdelaziz Ismail1, Olfat Elsayed Hassanein2, Randa Hafez2
1Department of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland; Department of Conservative Dentistry, Horus University in Egypt, New Damietta, Egypt.
Objectives:
to evaluate the clinical effectiveness of 1% dimethyl-sulfoxide (DMSO/H2O) dentin pretreatment on the clinical performance of 2-step etch-rinse adhesive after 36-months of a follow-up.
Methods:
Twenty-nine patients with 82 non carious-cervical lesions NCCLs were eligible for the study. NCCLs were randomly distributed into 2 equal groups. Both groups were acid etched then bonded with (Single-bond2, 3M-ESPE) and restored with a nanohybrid composite (Z350XT, 3M-ESPE) under rubber-dam isolation. Only for the intervention group 1% DMSO/H2O was applied for 60s then blot dried after etching and before bonding. The restorations were evaluated at baseline, 12-, 24-, and 36-months using FDI criteria for evaluation of the restoration. For the statistical analysis, intergroup comparison between interventions was performed using Chi-Square-test (P ≤ .05), intragroup comparison within each intervention was performed using the Cochran's Q-test (P ≤ .0083).
Results:
In the current study, intergroup comparison between both groups at baseline and after 12, 24 and 36 months showed no statistically significant differences for all tested outcomes (P > .05), except for marginal discoloration at 36 months, where there was statistically significant difference (P < .05) favoring DSMO. Intragroup comparison within control revealed statistically significant deterioration through time (P < .001) for all tested parameters, also within DSMO there was statistically significant change through time (P < .0083).
Conclusion:
The clinical performance of a 2-step etch-rinse adhesive in combination with 1% DMSO pretreatment was better than the control without pretreatment. Longer follow-up and higher concentrations of DMSO pretreatment should be evaluated in the future.
Clinical Significance:
Several laboratory studies showed that DMSO pretreatment improves the hybrid layer quality and integrity. However, this clinical trial gave the proof of the clinical effectiveness of this protocol after 36-months follow-up.
