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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Acrylated Bioengineered Mussel Protein-Based Adhesive Nanoparticles for Locoregional and Sustained Drug Delivery.

Jang Woo Yang1, Taehee Yoon1, Haram Kim2

  • 1Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.

ACS Biomaterials Science & Engineering
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PubMed
Summary

Bioengineered mussel adhesive protein nanoparticles offer improved drug delivery by adhering to tissues, enabling sustained release and enhanced retention. This approach overcomes common challenges for better therapeutic outcomes in cancer and regenerative medicine.

Keywords:
acrylation chemistrylocoregional drug deliverymussel adhesive proteinnanoparticlessustained drug release

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Nanoparticles are promising drug carriers but face clinical challenges like poor retention and burst release.
  • Mussel adhesive proteins (MAPs) offer strong wet adhesion properties.

Purpose of the Study:

  • To develop adhesive nanoparticles from bioengineered MAPs for improved drug delivery.
  • To enhance drug localization, retention, and sustained release at target sites.

Main Methods:

  • Acrylation of MAPs and photo-cross-linking to form polyacrylate-MAPs.
  • Characterization of nanoparticle adhesion, drug release kinetics, and retention capabilities.
  • In vitro and in vivo evaluation of therapeutic efficacy, including tumor growth suppression.

Main Results:

  • Acrylated MAP-based nanoparticles demonstrated superior wet adhesive properties.
  • Sustained drug release and long-term retention at administration sites were observed.
  • Effective tumor growth suppression was achieved with a single dose, maintaining therapeutic concentrations.

Conclusions:

  • Bioengineered MAP-based adhesive nanoparticles address key drug delivery challenges.
  • This technology shows potential for locoregional and sustained drug delivery in cancer therapy and regenerative medicine.