Quantitative assessment of bone mineral by photon scattering: calibration considerations

The ratio of the coherent-to-Compton photons scattered from bone can be used to measure its mineral density. Conversion of this ratio (R) to bone mineral density (BMD) requires calibration using bone simulating phantoms. The widely used aqueous solution of K2HPO4 proved unsatisfactory for calibration purposes when using the coherent-to-Compton technique. These solutions differ markedly in their scatter spectra and composition from trabecular bone. In this study a new and more realistic series of phantoms is proposed which simulates well the trabecular bone of the calcaneum. These phantoms are made of bone ash suspended in white petrolatum in varying concentrations. A calibration curve has been established using these phantoms with a range of BMD values of 0 to 347 mg/cm3. The scatter spectra, and range of R values and BMD of these phantoms are in very good agreement with those of real trabecular bone. A measuring device has been built for the determination of the BMD of the calcaneum by using the established calibration curve.