Related Experiment Video
Updated: May 21, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
469
Insular thyroid carcinoma: epidemiological pattern, factors contributing to recurrence and distant metastasis
Omar Hamdy1, Shadi Awny2, Mohamed H Sous3
1Surgical Oncology Department, Oncology Center, Mansoura University, Mansoura, 35516, Egypt. omarhamdy@mans.edu.eg.
BMC Endocrine Disorders
|May 7, 2025
Summary
Male sex, multifocality, and lack of radioactive iodine therapy impact survival in insular thyroid carcinoma patients. Optimal treatment involves surgery and adjuvant radioactive iodine therapy.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Insular thyroid carcinoma is a rare thyroid cancer subtype.
- It represents an intermediate category between differentiated and undifferentiated thyroid cancers.
Purpose of the Study:
- To analyze epidemiological, clinical, and oncological data of insular thyroid carcinoma patients.
- To identify factors affecting survival and recurrence in this rare cancer.
Main Methods:
- Retrospective study of insular thyroid carcinoma patients undergoing surgical treatment.
- Analysis of data from January 2009 to December 2023.
- Inclusion of 24 patients after screening 1690 thyroid cancer cases.
Main Results:
- Median time to recurrence was 24 months; median time to death was 55 months.
- Older age, comorbidity, multifocality, and lack of adjuvant RAI significantly impacted overall survival.
- Male sex and lack of adjuvant RAI were independent predictors of locoregional recurrence.
Conclusions:
- Male sex, multifocality, and absence of radioactive iodine therapy negatively affect survival.
- Complete surgical resection and adjuvant radioactive iodine therapy are crucial for managing insular thyroid carcinoma.
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