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Chilblain-like Lesion Associated With Coronavirus Disease 2019 Vaccine In Tropical Country: A Case Report.

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Chilblain-like Lesion Associated With Coronavirus Disease 2019 Vaccine In Tropical Country: A Case Report.

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Chilblain-like lesion associated with coronavirus disease 2019 vaccine in tropical country: a case report.

Wasuchon Chaichan¹, Mati Chuamanochan¹, Pongsak Mahanupab²

¹Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intavarorot Road, Sriphum District, Maung, Chiang Mai, 50200, Thailand.

Journal of Medical Case Reports

|May 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Chilblain-like lesions can occur after coronavirus disease 2019 vaccination. This case highlights a patient in Thailand who developed these symptoms, suggesting a potential link and the role of lupus anticoagulant.

Keywords:

COVID-19 vaccine Case report Chilblain-like lesion Chilblains Lupus anticoagulant

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Area of Science:

Dermatology
Immunology
Vaccinology

Background:

Chilblains are recognized as a skin reaction post-coronavirus disease 2019 (COVID-19) vaccination.
Limited case reports exist on chilblain-like lesions in tropical regions following COVID-19 vaccination.

Purpose of the Study:

To report a case of chilblain-like lesions associated with COVID-19 vaccination in Thailand.
To investigate potential contributing factors in a tropical setting.

Main Methods:

A case presentation of a 35-year-old Thai female patient.
Clinical observation of lesions post-mRNA-1273 vaccination.
Skin biopsy and laboratory workup, including lupus anticoagulant testing.

Main Results:

The patient developed painful, red papules on extremities 9 days after the first vaccine dose.
Skin biopsy confirmed chilblain histology.
Lupus anticoagulant was detected; lesions resolved spontaneously but recurred after the second dose.

Conclusions:

Chilblain-like lesions post-COVID-19 vaccination are reported in a tropical country (Thailand).
The presence of lupus anticoagulant may be a contributing factor to vaccine-associated chilblains.