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Unlocking miRNA Therapeutics: Protecting Liver Grafts and Suppressing HCC Recurrence

Daniel G Maluf1, Valeria R Mas2,3

  • 1Transplant Division, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.

Transplantation
|May 8, 2025
PubMed
Abstract

No abstract available in PubMed .

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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