Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereocontrolled spirocyclization of <i>exo</i>-glycals with arylamines for the synthesis of (1<i>S</i>)-spiro-tetrahydroquinoline glycosides.

Organic & biomolecular chemistry·2026
Same author

Identification and Biological Evaluation of (4H-Thieno[3,2-b]indol-3-yl)methanol as a Tumoricidal Scaffold for an Antineoplastic Agent.

Chemical biology & drug design·2025
Same author

The Effects of a Curcumin Derivative and Osimertinib on Fatty Acyl Metabolism and Mitochondrial Functions in HCC827 Cells and Tumors.

International journal of molecular sciences·2023
Same author

New metal-free one-pot synthesis of α-2-deoxy-Ulosides by microwave-assisted double Michael Addition of β-enamino ketones.

Carbohydrate research·2022
Same author

Exploitation of a rod-shaped, acid-labile curcumin-loaded polymeric nanogel system in the treatment of systemic inflammation.

Biomaterials advances·2022
Same author

Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity.

International journal of molecular sciences·2021

Related Experiment Video

Updated: Jun 21, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
09:10

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Published on: May 27, 2015

6.6K

Synthetic studies towards xanthomonadin.

Min-Tsang Hsieh1,2, Hui-Chang Lin1

  • 1School of Pharmacy, China Medical University, Taichung 406, Taiwan. T21917@mail.cmu.edu.tw.

Organic & Biomolecular Chemistry
|May 8, 2025
PubMed
Summary
This summary is machine-generated.

Researchers explored synthesizing the natural dye xanthomonadin 1. The key hydrobromination step yielded an unexpected bromo regioisomer, highlighting the influence of electronic effects on regioselectivity in polyene systems.

More Related Videos

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.5K
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

9.3K

Related Experiment Videos

Last Updated: Jun 21, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
09:10

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Published on: May 27, 2015

6.6K
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.5K
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

9.3K

Area of Science:

  • Organic Synthesis
  • Natural Product Chemistry
  • Catalysis

Background:

  • Xanthomonadin 1 is a natural dye with potential applications.
  • Efficient synthetic routes are crucial for natural product accessibility.
  • Hydrobromination of polyene systems is a key synthetic transformation.

Purpose of the Study:

  • To develop a synthetic strategy for xanthomonadin 1.
  • To investigate the hydrobromination of a heptaene ester intermediate.
  • To understand the regioselectivity of the hydrobromination reaction.

Main Methods:

  • Synthetic organic chemistry techniques were employed.
  • A specific catalyst system (CuO/4,7-(MeO)2phen/[EMIM]) was utilized for hydrobromination.
  • Analysis of reaction products to determine regioselectivity.

Main Results:

  • The hydrobromination of the heptaene ester yielded a bromo regioisomer, not xanthomonadin 1.
  • The regioselectivity was influenced by the number of conjugated double bonds in the polyene system.
  • Evidence for the impact of electron push-pull effects on the reaction outcome was observed.

Conclusions:

  • The developed hydrobromination method did not produce the target xanthomonadin 1.
  • The study provides insights into controlling regioselectivity in polyene functionalization.
  • Further optimization is needed for the synthesis of xanthomonadin 1 and related compounds.